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Please consult your physician before taking any medication. Generic Glucovance 60 Tabs 2.5/500mg - Glyburide/Metformin Generic Name: Glyburide/Metformin Tablets (GLYE-bure-ide/met-FOR-min) Brand Name: Glucovance Glyburide/Metformin is used for: Treating type 2 diabetes. It is used along with diet and exercise. It may be used alone or with other antidiabetic medicine. Glyburide/Metformin is a sulfonylurea and biguanide antidiabetic combination. It causes the pancreas to release insulin, which helps to lower blood sugar levels. It also decreases the amount of sugar that the liver produces and the intestines absorb. It also helps to make your body more sensitive to the insulin that you naturally produce.