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Prazosin is a hypotensive agent that is also an alpha-blocker. The drug lowers blood pressure and has a beneficial effect on the heart with heart failure. The main action of the substance is vasodilation. Due to the expansion of veins and arteries, the drug reduces peripheral resistance and facilitates the work of the heart.
In our Mexican pharmacy you can buy Prazosin in a dosage of 1 mg. Please follow your doctor's recommendations to avoid side effects.
Selectively blocks postynaptic alpha1-adrenergic receptors. It is quickly absorbed in the gastrointestinal tract, the absorption rate does not depend on food intake. Bioavailability is 50–85%. In the blood, bound to proteins by 97%. As a result of degradation, 4 metabolites are formed in the liver, which account for up to 25% of pharmacological activity. T1 / 2 - 2-4 hours, with renal failure and in the elderly, it increases. Excreted mainly by bile.
It has a pronounced hypotensive effect without a significant increase in heart rate. Reduces total peripheral vascular resistance, expands capacitive and resistive vessels. Significantly reduces pressure in the pulmonary veins and right atrium, moderate - pulmonary vascular resistance. Taking the first dose often causes a sharp drop in blood pressure (especially in orthostasis and while taking diuretics). After cancellation and subsequent administration within a week, a similar effect from taking the first dose is not observed. Reduces myocardial oxygen demand, increases stroke volume during physical exertion. It has a minimal effect on fluid retention in the body, does not increase body weight, does not change the filtration rate and renal blood flow, and reduces the resistance of renal vessels. The peak of the hypotensive effect after a single dose is observed after 1–4 hours, the duration is up to 10 hours. Both early (by 4–5 days) and late (by 12 months) tolerance can develop, which requires an increase in dose. Favorably affects the lipid spectrum: the level of total cholesterol, triglycerides, VLDL and LDL decreases; does not alter carbohydrate tolerance or uric acid metabolism.
Prazosin is prescribed for the following disorders and diseases:
• Arterial hypertension;
• Chronic heart failure (as an additional treatment to the main therapy);
• Syndrome and Raynaud's disease;
• Pheochromocytoma, spasm of peripheral vessels against the background of poisoning by ergot alkaloids;
• Prostate hyperplasia.
Contraindications to the use of the drug Prazosin are:
• Hypersensitivity to any components of the drug;
• Heart failure with constrictive pericarditis;
• Cardiac tamponade, malformations with reduced left ventricular filling pressure;
• Age to 12 years
With caution, the medication must be used for hyponatremia.
The drug Prazosin is taken orally before bedtime in a horizontal position (at the beginning of the course of treatment. The initial dosage is 0.5-1 mg. Then Prazosin is taken 2-3 times a day for 1 mg. Every 5-7 days of administration, you can switch from one dosage to a higher one (6-15 mg for 2-3 doses per day.) The daily maximum dose is 20 mg. The maximum effect appears after 4-6 weeks of treatment.
Dosage and treatment should be determined by your doctor depending on your specific case.
Prazosin enhances the action of diuretics and beta-blockers.
An overdose of Prazosin can cause the following disorders: tachycardia, circulatory disorders, angina attacks, myiasis, heart rhythm disturbance, oliguria, anuria. The first aid for an overdose is laying the victim in a horizontal position. Legs must be lifted up. If necessary, norepinephrine is administered. Next, you need to restore the water-salt balance in the body.
The following side effects may occur while taking Prazosin:
• Dizziness, headache, fainting;
• Insomnia, fatigue, weakness, depression, nervousness;
• Rapid urination, swelling of the lower extremities;
• Nausea, constipation, diarrhea;
• Dry mouth.
In some cases, Prazosin may cause a rapid heartbeat. Elderly people should be careful in choosing a dosage, as the strength and effect of the drug increases with age. High probability of hypotension.
In order to control the occurrence of hypotension, it is necessary to constantly monitor the level of heart rate and blood pressure while taking the drug.
Compassionate advice your specialist before taking any remedy. Brand name: Minipress Generic name: Prazosin hydrochloride Why is Minipress embraced? Minipress is used to treat hypertension. It is effective used alone or with other hypertension arrangements, for instance, diuretics or beta-blocking pharmaceuticals (sedates that straightforwardness heart withdrawals, for instance, atenolol. Minipress is furthermore embraced for the treatment of positive prostatic hyperplasia (BPH), an odd development of the prostate organ. Minipress may moreover be used for purposes other than those recorded in this pharmaceutical helper.